Tucker suspects that his best friend has a problem with drugs and alcohol, but Hank is able to diagnose a medical condition causing his problems. Divya meets a woman who works at the vineyard where the episode takes place and determines the cause of her ageusia.
Hank goes head-to-head with Emily Peck treating a patient, who despite having a shin injury, begins losing his vision. Evan, meanwhile, is approached by the patient's girlfriend with a bizarre proposition, while Divya treats a couple whose marriage has spontaneously collapsed, leading to an odd medical answer to their troubles.
Jill's struggle for the free clinic against Dr. Blair continues, but the situation becomes complex when her estranged husband calls Hank to treat their son. Evan attempts to fit in with Paige's family, and Hank and Emily Peck's relationship develops.
The team treat a lottery-winning couple who seem to have been struck with the "lottery curse". Divya treats a kidney-transplanted housekeeper while trying to ignore her budding attraction to her patient's employer.
Tensions grows between Hank and Emily when they care for a patient together but disagree on the course of treatment. Evan concocts a cyber retaliation plan against Emily, who has managed to direct web traffic to her site.
Hank attempts to deal with a talkative socialite, whose indistinct condition leaves the whole team confused. Adam, the kidney donor from "Whole Lotto Love", calls Divya once again with problems of his own. Evan attempts to unravel the mystery of Eddie's covert meetings.
On the green at the hospital's golf charity drive, Hank tries to help a golfer (Tom Cavanagh) with a hooked hand, while Jill begins to succumb to an exhausting condition. Boris considers options open to dealing with Eddie, and Divya strains her professional and personal life because of Adam.
Jill's backyard is overtaken by jetsetting reality TV show stars, whose various health problems are complicated by the 24-hour cameras. Dr. Peck returns with a new deal, while Marisa tries to keep her pregnancy and career under control.
HankMed treats an aspiring singer. Meanwhile, Evan overhears General Collins's plans for his Senate campaign, and Divya continues to worry about her emotional investment in Adam. Dr. Peck becomes Eddie's physician, which upsets Hank.
With the storm of the year bearing down on the Hamptons, HankMed continues to search for Divya's replacement, while treating a park ranger who was struck by lightning. Divya treats a storm chaser whose high-risk lifestyle is at odds with her condition.
A year after a stock trader's friend dies in the emergency room, she begins to feel similar symptoms—which is concerning for her literal high-flying lifestyle. Raj's lateness for his wedding party for their American friends forces him to reveal a problem with the company, and Evan bites more off than he can chew while trying to deal with Paige's snoring.
Hank is worried that his patient had been misdiagnosed twenty years ago, and wants to get to the bottom of the case. Meanwhile, Divya and Raj take dance lessons in preparation for their wedding, but they end up as patients themselves. Eddie struggles to choose between a life on the run without his boys, or life in a low security prison with a chance to still see them occasionally. Jill is faced with the chance to take a job out of the country, or stay in her current job and maintain the clinic.